Mushroom poisoning is increasing worldwide, as well as the incidence of fatal mushroom
poisoning. Several new syndromes associated with mushroom poisoning have been described
in the literature. Notably, 1 of the newly identified mushroom poisonings is Russula subnigricans poisoning. R subnigricans can be classified as causing a delayed-onset rhabdomyolytic syndrome as patients
with this severe poisoning present with severe rhabdomyolysis, acute kidney injury,
and cardiomyopathy. However, there are only a few reports on the toxicity of R subnigricans. We recently treated 6 patients with R subnigricans mushroom poisoning, of whom 2 died. The 2 patients showed severe rhabdomyolysis,
metabolic acidosis, acute renal failure, electrolyte imbalance, and irreversible shock,
which caused their deaths. Mushroom poisoning should be considered in the evaluation
of rhabdomyolysis of unknown origin. In addition, in cases of mushroom poisoning with
severe rhabdomyolysis, R subnigricans poisoning should be promptly identified.
Keywords
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References
- Approach to mushroom intoxication and treatment: can we decrease mortality?.Clin Res Hepatol Gastroenterol. 2012; 36: 139-145
- Mushroom poisoning epidemiology in the United States.Mycologia. 2018; 110: 637-641
- Syndromic diagnosis and management of confirmed mushroom poisonings.Crit Care Med. 2005; 33: 427-436
- Demographic, clinical, and laboratory findings of mushroom-poisoned patients in Kermanshah Province, west of Iran.BMC Pharmacol Toxicol. 2022; 23: 1-7
- Mushroom poisoning outbreaks - China, 2021.China CDC Wkly. 2022; 4: 35-40
- Investigation and analysis of 102 mushroom poisoning cases in Southern China from 1994 to 2012.Fungal Divers. 2014; 64: 123-131
- Accidental poisoning by death cap mushrooms: be careful what you eat.Wilderness Environ Med. 2013; 24: 168-170
- Russula subnigricans poisoning causes severe rhabdomyolysis that could be misdiagnosed as non-ST segment elevation myocardial infarction.Wilderness Environ Med. 2022; 33: 324-328
- New syndromes in mushroom poisoning.Toxicol Rev. 2006; 25: 199-209
- Mushroom poisoning: a proposed new clinical classification.Toxicon. 2019; 157: 53-65
- Toxic potential of traditionally consumed mushroom species—a controversial continuum with many unanswered questions.Toxins. 2020; 12: 639
- Species delimitation of three species within the Russula subgenus Compacta in Korea: R. eccentrica, R. nigricans, and R. subnigricans.J Microbiol. 2014; 52: 631-638
- Rhabdomyolysis: an unusual feature with mushroom poisoning.Am J Kidney Dis. 2001; 38: E17.1-E17.5
- A case of mushroom poisoning with Russula subnigricans: development of rhabdomyolysis, acute kidney injury, cardiogenic shock, and death.J Korean Med Sci. 2016; 31: 1164-1167
- Russula subnigricans poisoning: from gastrointestinal symptoms to rhabdomyolysis.Wilderness Environ Med. 2015; 26: 380-383
- Demographic and epidemiologic evaluation of mushroompoisoning: a retrospective study in 4-year admissions of Razi Hospital (Qaemshahr, Mazandaran, Iran).Med Glas. 2020; 17: 117-122
- Elevated serum cardiac troponin I in rhabdomyolysis.Int J Cardiol. 2004; 96: 35-40
- Identification of cyclopropylacetyl-(R)-carnitine, a unique chemical marker of the fatally toxic mushroom Russula subnigricans.Chem Pharm Bull. 2016; 64: 602-608
- Toxicological profiles of poisonous, edible, and medicinal mushrooms.Mycobiology. 2014; 42: 215-220
Article info
Publication history
Published online: May 18, 2023
Accepted:
March 20,
2023
Received:
November 25,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.